In this issue of Sleep Medicine Clinics, guest editor Dr. Matthew R. Ebben brings his considerable expertise to the topic of PAP Therapy for the Treatment of OSA. Positive airway pressure (PAP) is the treatment of choice for patients with moderate-to-severe obstructive sleep apnea (OSA). Randomized controlled trials have demonstrated that PAP can effectively reduce the apnea-hypopnea index and improve subjective and objective sleepiness. In this issue, top experts provide an up-to-date review of PAP therapy for the treatment of OSA. Contains 14 practice-oriented topics including racial differences in PAP adherence in the treatment of sleep apnea; cost/benefit analysis of CPAP vs other treatments for OSA; best predictors of PAP compliance; the effect of insomnia on OSA treatment; cognitive complaints and comorbidities that present in patients with OSA; and more. Provides in-depth clinical reviews on PAP therapy for the treatment of OSA, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.